Clinical trials tranformation intiative-decentralized clinical trials: a review article

In clinical research, Decentralized trials (DCTs) can provide opportunities to maximize efficiencies. Unlike the traditional trial model, Clinical Trials promote telemedicine, mobile/local healthcare providers (HCPs), mobile/web-based technology, and direct distribution of Investigational Medicinal Products (IMP) patients, among other things. Hence, DCTs are in spotlight as infrastructure, knowledge providing a backbone research.
 Background: Advances electronic communication, data storage, emerging technologies, biosensor development provides new exchange information, such patient is tested from their home locations with distant investigator. that take place at investigator (i.e., spectrum: CCTs → Hybrid Models DCTs) any or all study-related procedures collected electronically fall category decentralized trial. should be designed integrate current system study subject, optimize convenience for subjects advantage existing programs sources including The themselves through utilization telecommunication, videoconferences, mobile internet-based tools reporting, technology biosensors. Local providers, home-based services, pharmacies, clinics, regional hospitals, perceived obstacles have impeded widespread use devices trials. To encourage solutions these challenges, Trial Transformation Initiative (CTTI) has released best practices practical methods advance issues sponsors now use.
 Conclusion: not only operationally feasible show high recruitment rates, better compliance, lower dropout conducted faster. DCT meets goal industry being low-risk, returns offer reliable, time-based, cost-effective approach.